Multiclass Multi-Residue Analysis of >100 Veterinary Drug Residues in Bovine Tissues by Filter Vial Dispersive-SPE & LC-MS/MS

Poster presented at AOAC 2015
Steven J. Lehotay, Marilyn J. Schneider, and Alan R. Lightfield
U. S. Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center; 600 East Mermaid Lane; Wyndmoor, PA 19038; USA

High-throughput analysis is needed to meet demand for monitoring of veterinary drug residues in food animal tissues. The current veterinary drug residue monitoring method used by the USDA Food Safety and Inspection Service (FSIS) uses a combination of hexane-partitioning, dispersive-SPE, and solvent evaporation to achieve adequate cleanup for 20 mg equivalent sample injections to meet regulatory detection limit needs. This extra effort adds to the time and cost of the method and limits sample throughput. An improved method is developed and validated to streamline the sample preparation and LC-MS/MS method for identification and quantification of >120 veterinary drugs in bovine animal tissues for use in high throughput monitoring in the FSIS National Residue Program.

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Title

Multiclass Multi-Residue Analysis of >100 Veterinary Drug Residues in Bovine Tissues by Filter Vial Dispersive-SPE & LC-MS/MS

Description

High-throughput analysis is needed to meet demand for monitoring of veterinary drug residues in food animal tissues. The current veterinary drug residue monitoring method used by the USDA Food Safety and Inspection Service (FSIS) uses a combination of hexane-partitioning, dispersive-SPE, and solvent evaporation to achieve adequate cleanup for 20 m...

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Product Used

eXtractor3D|FV® - PVDF 0.2µm

Non-Split Septum, Red Cap

pn#95531-200

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