Plasticizers content in Filter Vials Compared to Syringe Filters

Testing by Takeda Pharmaceutical Company Limited® UPLC - ELSD*
*Thomson is not affiliated with Takeda Pharmaceutical Company or its subsidiaries

Introduction

Thomson Filter Vials are manufactured without the use of plasticizers or mold release agents, making them LC/MS clean. Testing with ELSD, PDA, and MS detection by Takeda Pharmaceutical showed no leaching from Thomson Standard Filter Vial with a 0.45um, PTFE membrane compared to significant leaching from Millipore Millex-FH® Filter, 0.45M, hydrophobic PTFE, 4mm. Method: A. Water B. ACN 45-90% with .05% TFA Ballistic Gradient over 1.4 minutes using Waters® Acquity® UPLC Thomson Filter Vial (patented) Part # 35540-500 Filter Vial 0.45μM hydrophobic PTFE, w/ Pre-Slit Cap Millipore Syringe Filter Part #:SLFHR04NL Millex-FH® Filter, 0.45M, hydrophobic PTFE, 4mm, non-sterile.

Method

A. Water
B. ACN 45-90% with 0.05% TFA

Ballistic Gradient over 1.4 minutes using Waters® Acquity® UPLC

Thomson Standard Filter Vial

0.45μm hydrophobic PTFE, w/ Pre-Slit Cap
Part #: 35540-200

Millipore* Syringe Filter

Millex-FH® Filter, 0.45μm, hydrophobic PTFE, 4mm, non-sterile.
Part #: SLFHR04NL

plasticizer 1 plasticizer 2 plasticizer 3 plasticizer 4 plasticizer 5 plasticizer 6

*Thomson is not affiliated with Millipore or its subsidiaries

Title

Plasticizers content in Filter Vials Compared to Syringe Filters

Description

Thomson Filter Vials are manufactured without the use of plasticizers or mold release agents, making them LC/MS clean.

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Product Used

Standard|Filter Vial - PTFE 0.45µm

Standard|Filter Vial - PTFE 0.45µm

Pre-Split Septum, Blue Cap

pn#35540-200

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