Plasticizers content in Filter Vials Compared to Syringe Filters
Testing by Takeda Pharmaceutical Company Limited® UPLC - ELSD*
*Thomson is not affiliated with Takeda Pharmaceutical Company or its subsidiaries
Introduction
Thomson Filter Vials are manufactured without the use of plasticizers or mold release agents, making them LC/MS clean. Testing with ELSD, PDA, and MS detection by Takeda Pharmaceutical showed no leaching from Thomson Standard Filter Vial with a 0.45um, PTFE membrane compared to significant leaching from Millipore Millex-FH® Filter, 0.45M, hydrophobic PTFE, 4mm. Method: A. Water B. ACN 45-90% with .05% TFA Ballistic Gradient over 1.4 minutes using Waters® Acquity® UPLC Thomson Filter Vial (patented) Part # 35540-500 Filter Vial 0.45μM hydrophobic PTFE, w/ Pre-Slit Cap Millipore Syringe Filter Part #:SLFHR04NL Millex-FH® Filter, 0.45M, hydrophobic PTFE, 4mm, non-sterile.
Method
A. Water
B. ACN 45-90% with 0.05% TFA
Ballistic Gradient over 1.4 minutes using Waters® Acquity® UPLC
Thomson Standard Filter Vial
0.45μm hydrophobic PTFE, w/ Pre-Slit Cap
Part #: 35540-200
Millipore* Syringe Filter
Millex-FH® Filter, 0.45μm, hydrophobic PTFE, 4mm, non-sterile.
Part #: SLFHR04NL






*Thomson is not affiliated with Millipore or its subsidiaries
Title
Plasticizers content in Filter Vials Compared to Syringe Filters
Description
Thomson Filter Vials are manufactured without the use of plasticizers or mold release agents, making them LC/MS clean.
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