Plasticizers content in Filter Vials Compared to Syringe Filters

Testing by Takeda Pharmaceutical Company Limited® UPLC - ELSD*
*Thomson is not affiliated with Takeda Pharmaceutical Company or its subsidiaries

Introduction

Thomson Filter Vials are manufactured without the use of plasticizers or mold release agents, making them LC/MS clean. Testing with ELSD, PDA, and MS detection by Takeda Pharmaceutical showed no leaching from Thomson Standard Filter Vial with a 0.45um, PTFE membrane compared to significant leaching from Millipore Millex-FH® Filter, 0.45M, hydrophobic PTFE, 4mm. Method: A. Water B. ACN 45-90% with .05% TFA Ballistic Gradient over 1.4 minutes using Waters® Acquity® UPLC Thomson Filter Vial (patented) Part # 35540-500 Filter Vial 0.45μM hydrophobic PTFE, w/ Pre-Slit Cap Millipore Syringe Filter Part #:SLFHR04NL Millex-FH® Filter, 0.45M, hydrophobic PTFE, 4mm, non-sterile.

Method

A. Water
B. ACN 45-90% with 0.05% TFA

Ballistic Gradient over 1.4 minutes using Waters® Acquity® UPLC

Thomson Standard Filter Vial

0.45μm hydrophobic PTFE, w/ Pre-Slit Cap
Part #: 35540-200

Millipore* Syringe Filter

Millex-FH® Filter, 0.45μm, hydrophobic PTFE, 4mm, non-sterile.
Part #: SLFHR04NL

plasticizer 1 plasticizer 2 plasticizer 3 plasticizer 4 plasticizer 5 plasticizer 6

*Thomson is not affiliated with Millipore or its subsidiaries

Product Used

Standard|Filter Vial - PTFE 0.45µm

Pre-Split Septum, Blue Cap

pn#35540-200

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