Title

Process development for production of nonoriginator NISTmAb from CHO and NS0 cell lines

Description

We identified agitation rates and gassing strategy as critical process parameters for NISTCHO stirred-tank bioreactor operations and established processes for fed-batch and perfusion rocking bioreactor operations. We anticipate this work to benefit the growing number of researchers employing non-originator NISTmAb-expressing cell lines to support ...

Process development for production of nonoriginator NISTmAb from CHO and NS0 cell lines

Erica J. Fratz-Berilla, Nicole Azer, Xin Bush, JungHyun Kim & Casey
Kohnhorst (2025) Process development for production of non-originator NISTmAb from CHO
and NS0 cell lines, mAbs, 17:1, 2505088, DOI: 10.1080/19420862.2025.2505088

We identified agitation rates and gassing strategy as critical process parameters for NISTCHO stirred-tank bioreactor operations and established processes for fed-batch and perfusion rocking bioreactor operations. We anticipate this work to benefit the growing number of researchers employing non-originator NISTmAb-expressing cell lines to support precompetitive innovation in biomanufacturing.

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