Groundwater is an important component in many industrial processes as well as irrigating our crops and recharging lakes, rivers and wetlands. Groundwater supplies drinking water for 51% of the total U.S. population and 99% of its rural population. Unfortunately, groundwater is susceptible to pollutants due to the widespread use of pesticides and fertilizers. Traditionally, syringe filtration or centrifugation have been used to remove particulates and reduce possible matrix interference prior to LC/ MS analysis. However, these techniques are time consuming, adversely impact reproducibility and quantification. We investigated the potential for streamlining sample preparation method for the analysis of Prosulfuron and its metabolites in ground water using the Thomson Standard|FV compared to syringe filtration and centrifugation.