Title

Time and Cost Effective Methods for Reducing Background Noise and Signal Suppression in Problem Matrices for Residue Analysis by LC-MS/MS

Description

Several clean-up methods are compared for background reduction, analyte recovery, and cost effectiveness in order to successfully analyze a wide variety of multiclass multiresidues in difficult matrices including Chili Powder and Tobacco. The most critical aspects of reliable multiresidue analysis are the reduction of interferences from the sample...

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Time and Cost Effective Methods for Reducing Background Noise and Signal Suppression in Problem Matrices for Residue Analysis by LC-MS/MS

Presented at NACRW 2016
Joseph Kolb1, Ariana Ramdin1, Ryan Undeen1
1Merieux NutriSciences Corporation, Gainsville, FL 32607

Several clean-up methods are compared for background reduction, analyte recovery, and cost effectiveness in order to successfully analyze a wide variety of multiclass multiresidues in difficult matrices including Chili Powder and Tobacco. The most critical aspects of reliable multiresidue analysis are the reduction of interferences from the sample matrix and analyte recovery. eXtreme|FV®, were compared to an existing ISO accredited QuEChERS method, as well as a dilute and shoot approach are analyzed in conjunction with different filtration techniques for residue analysis by LC-MS/MS for minimal number of steps, speed, reduced reagent use and reduced cost.

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