Improved Method for the Analysis of 31 Drugs of Abuse/Pain Management Panel in Oral Fluid Samples using the Thomson eXtreme|FV® by LC-MS/MS

Poster presented at MSACL 2015
Nadine Koenig1, Crystal Xander1, Melanie Stauffer1, Dean Fritch2, Lisa Wanders3, Sam Ellis3
1Health Network Laboratories, 794 Roble Road, Allentown, PA 18109
2OraSure Technologies, Inc. 150 Webster Street, Bethlehem, PA 18015
3Thomson Instrument Company, 1121 South Cleveland Street Oceanside, CA 92054

The goal of this study was to improve the sample preparation for the analysis of drugs of abuse/pain management panels in oral fluids. The oral fluid samples were collected with Intercept® i2he™ Oral Fluid Collection Devices. The diluted oral fluid samples were filtered using Thompson Filter Vials, followed by LC/MS/MS analysis. The most critical aspects of reliable Oral Fluid analysis are the reduction of interferences from the sample matrix and analyte recovery. Traditionally, SPE, SLE and centrifugation have been used to reduce matrix interference prior to MS analysis. However, these techniques are time consuming, adversely impact recovery, require expensive consumables and equipment and use large amounts of solvent. Thomson eXtreme® Filter Vials (patented) offer multi-layer filtration for viscous samples and samples containing up to 30% solid particulates.

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Title

Improved Method for the Analysis of 31 Drugs of Abuse/Pain Management Panel in Oral Fluid Samples using the Thomson eXtreme|FV® by LC-MS/MS

Description

The goal of this study was to improve the sample preparation for the analysis of drugs of abuse/pain management panels in oral fluids. The oral fluid samples were collected with Intercept® i2he™ Oral Fluid Collection Devices. The diluted oral fluid samples were filtered using Thompson Filter Vials, followed by LC/MS/MS analysis. The most critical ...

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Products Used

eXtreme|FV® - PVDF 0.2µm

Pre-Split Septum, Red Cap

pn#85531-200

Multi-Use Press

48 Position for Autosampler Ready Filter Vials

pn#35015

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