The most critical aspects of reliable food contamination analysis are the reduction of interferences from the sample matrix and analyte recovery. Traditionally, SPE, SLE, Liquid-Liquid, syringe filtration, and centrifugation have been used to reduce matrix interference prior to LC/MS analysis. However, these techniques are time consuming, adversely impact recovery, require expensive consumables, and use large amounts of solvent (which need to be concentrated). Several studies were undertaken to investigate whether four different types of filter vial designs offered improved clean-up methods.